Noopept Review: Benefits, Side Effects, Dosage, Risk, etc.

Noopept is a powerful nootropic said to be 1000 times stronger than Piracetam. The two shares similar effects only that Noopept magnifies it a thousand times. In this Noopept review, we will take a look at this nootropic’s benefits, side effects, contraindications, dosage, and more.

What is Noopept?

Noopept review

Noopept is a brand name for a substance called N-phenylacetyl-L-prolylglycine ethyl ester. It also comes by the name of Noopeptide and GVS-111.

Noopept was first developed in Russia during the ‘90s. It’s still in use as a prescription drug for traumatic brain injury, cognitive disorders, and age-related cognitive decline among others.

As a synthetic nootropic, it has stronger cognitive effects. It’s also said to have better neuroprotective properties than racetam drugs. Latest studies indicate that Noopept might have potential as an anxiolytic nootropic.

The effects of Noopept are usually compared to Piracetam. However, Noopept has a very different chemical structure. It lets the nootropic be absorbed faster and has a stronger effect than typical racetams.

Who uses Noopept?

At first, Noopept was just a prescription drug in Russia set to aid brain-related conditions. But later on, as more and more people learn about the cognitive effects of the drug, Noopept is being sold as a nootropic.

Some will use it to boost their brain performance for an upcoming exam while there are some who would utilize it to improve their performance at work.

Still, Noopept isn’t one without some downsides. Below, we outlined the benefits and risks of this drug for your guidance.

How Noopept works inside the body

When a person takes Noopept, it will be metabolized in the liver and absorbed in the digestive system. Noopept doesn’t need a carrier drug to pass the blood-brain barrier which allows faster absorption.

Once it’s in the bloodstream, Noopept will now have an effect on a person’s cognitive performance. Usually, the process takes no more than 20 minutes which is way faster than caffeine.

Noopept review

When Noopept reaches the brain, it will then interact with the acetylcholine synthesis to boost the neurotransmitter’s effect. The person will experience better cognition and learning.

Also, studies found that Noopept helps keep glutamate transmission in normal levels. In the long run, it will help protect the brain from glutamate damage. It’s the reason why Noopept has neuroprotective properties.

Noopept also has anti-inflammatory and antioxidant properties that also contribute to its neuroprotectant abilities. By reducing excess glutamate in a person’s system, Noopept can also help improve your blood composition.

Health Benefits of Noopept

Noopept has many health benefits mostly related to brain functions. Here are some of the main perks:

*Better learning

Since Noopept is made to cure cognitive impairment, there’s no doubt that it can help individuals boost their memory.

Noopept, like Piracetam, helps in memory formation which is why individuals who take it report better recall. According to the Russian pharmaceutical that produces the drug, Noopept acts in all phases of memory processing.

Aside from treating learning impairments, Noopept also helps treat alcohol-related brain damage, stroke, organic brain disease, and neurodegeneration.

*Protecting the brain

Studies have proven that Noopept isn’t just a potent smart drug; it can also protect the brain from damages. As an antioxidant, Noopept can shield the brain from oxidative damage due to contaminants and free radicals.

Oxidative damage is related to Alzheimer’s disease and other neurodegenerative conditions. And thanks to its anti-inflammatory capabilities, Noopept can boost spatial reasoning, verbal proficiency, executive function, and more.

*Reducing anxiety

Latest studies found out that Noopept has the potential to reduce anxiety. For those with mild cognitive disorders, taking Noopept twice a day in a 10 mg dosage can actually reduce anxiety.

Even personal experiences of Noopept users attest to its anxiolytic benefits. However, there are some who complain about jitters where the drug made them more anxious.

This part begs for more studies but the initial findings look really promising.

*Removes brain fog

Brain fog is a common complaint among students and office workers. With Noopept working, the brain will have better sensitivity with acetylcholine.

Acetylcholine is a neurotransmitter that’s responsible for the function of various brain signals. If the brain is more reactive to this neurotransmitter, brain fog will not happen.

With the brain signals efficiently working, the person will experience a clear mind.

*Stress buster

Noopept is actually a better mood enhancer than Piracetam.

Benzodiazepine receptors located in the brain’s hippocampus regulate your stress levels. What Noopept does is its main metabolite interacts with the receptors to reduce the stress. It’s also the reason why there’s a strong belief about Noopept’s anxiolytic properties.

Potential side effects

Like any other drug, Noopept has potential side effects. Take note that most of these side effects will depend on the condition of the person taking the drug.

Generally, Noopept is a safe drug if taken in the right dosage. Still, some individuals may experience minor side effects like irritability, jitters, restlessness, headaches, and dizziness. These are usually the case if Noopept is taken beyond the recommended amount.

Some people would experience insomnia, stomach ache, and fatigue when taking Noopept. As a nootropic, its effects will vary per user.

Things can go really bad if Noopept is taken haphazardly.  Again, it’s still a drug. If you have an underlying condition or planning to use the nootropic for treatment, it’s imperative to consult with a physician first.

Proper dosing

Noopept is usually taken once or twice daily between 10 and 30 mg. The drug should be taken after a meal. Take note, though, that taking this drug in the late afternoon can cause insomnia.

Also, Noopept shouldn’t be taken continuously. For a formal Noopept treatment, it will last between one and a half to three months. If a physician deems it’s necessary to start another cycle, the person would have to wait for at least one month before taking the drug again. This will prevent tolerance and dependence.

For newbie users, it’s advised to start with the smallest possible dose. Increase only if the effect isn’t on par with your physician’s expectations. If you’re planning to increase your intake, consult your physician so they can advise about the possible side effects.

If you experience harsh effects, discontinue the usage and consult with a doctor.

How to stack

Noopept has great benefits if taken as a standalone nootropic. But to boost its benefits and reduce the possible negative effects, it can be stacked with other nootropics.

Here are some of the sample stacks that you can consider. Again, talk to a doctor first before taking any of these drugs:

*Stacking with racetams

Some would say that pairing Noopept with a racetam can ruin the former’s effects. It’s actually the other way around. Noopept and racetams target different parts of the brain which means it won’t cause overload if you properly stack them together.

With the right dosage, racetams and Noopept can have synergistic effects.

*Stacking with Choline

Choline keeps the brain well-oiled to avoid brain fog and jitters. If stacked with Noopept, it can actually add a soothing effect among its users.

Choline will also prevent headaches that Noopept may bring on the initial phases of usage. Nagging headaches will no longer be your problem when you stack it with a high-quality Choline source like Alpha GPC.

*Stacking with Piracetam and Choline

You can stack Noopept with two other nootropics. Here, you can combine Choline and Piracetam with Noopept to target multiple neurotransmitters.

By adding Choline into the stack, you can put off the headaches while boosting the effects of Piracetam.

*Stacking with Sulbutiamine and Aniracetam

In this stack, you’re going to add a racetam and Sulbutiamine, a synthetic substance similar to thiamine. It can increase the thiamine supply in the brain which can be a stimulant for better performance among athletes.

This stack can boost cognition while adding an anxiolytic effect. However, you should cycle Sulbutiamine to avoid tolerance buildup.


Pregnant and lactating women should refrain from taking Noopept. It’s also not advisable among individuals with kidney or liver malfunction.

Also, those with lactose intolerance should consult with their doctor first. Children under 18 years of age should also avoid taking Noopept unless a physician prescribes so.

If you have hypertension, Noopept may cause complication as it tends to increase blood pressure. For those with hypersensitivity to the components of Noopept might experience negative effects.

Generally, you should consult a doctor if you’re planning to ingest Noopept. Ill or not, the advice of a medical professional is indispensable.

Where can you buy Noopept?

Noopept isn’t usually available on drugstores or physical pharmacies. If you need to take it, a doctor can supply it to you or you will purchase it online. Here’s where you can purchase Noopept.

Take note that proper dosage is important to avoid any untoward effects.


We hope that this Noopept review helped you in using the nootropic. Regardless of your condition, it’s always imperative to ask the advice of a medical professional. Noopept is a powerful nootropic, but if taken haphazardly, it may do more harm than good

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Noopept Review: Benefits, Side Effects, Dosage, Risk, etc.

by admin time to read: 6 min